How to Avoid 3 Key Sources of Error in Adaptive Trials


Adaptive design is a novel clinical trial approach that is supposed to maximise efficiency and portfolio value. So why do manufacturers fail to benefit in certain cases?

In the Operational Challenges of Adaptive Trials: Integrated Technology and Best Practices for Successful Implementation white paper, you’ll discover:

  • How to overcome three critical operational challenges that could prevent success in an adaptive clinical trial
  • Four criteria you should fulfil in order to ensure a robust technology infrastructure for adaptive design
  • Several real-world examples of adaptive design errors and how to fix them

Case Study: A Cautionary Case Study on Avoiding Operational Errors in Adaptive Trials

Despite early signs of efficacy, an adaptive Phase III superiority trial for a new chronic graft-versus-host disease treatment failed after being halted. Learn how the erroneous early stopping decision could have been prevented.

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Case Study: Mitigating Development Risks through Adaptive Design

After running for seven years, an adaptive Phase II trial for acute infectious diarrhea fell prey to operational bias during interim analysis. Learn which procedures could have enabled the study to maintain blinding.

Case study thumbnailCase Study:Mitigating Development Risks through Adaptive Design Read the case study