Glucose Clamp Techniques for Advancing the Development of Diabetes Type I and Type II Therapeutic Agents

• Clamp procedure development: historical review
• Operational considerations and points of reference
• Types of clamps & Applications
• Documented regulatory authority and industry recognition of the clamp procedure

Use of Glucose Clamping and Stable Isotopes to Understand Glucose Production and Utilization in Human Subjects

• When to incorporate clamps in the development process
• Consideration in protocol design (insulin infusions, insulin priming etc.)
• The use of isotopes in clamps and examples of isotope data analysis

The Hyperglycemic Clamp as a Method for Assessing Beta-Cell Sensitivity and Insulin Resistance
Benefit of hyperglycemic clamp as opposed to other methods of assessing beta-cell response

• Hyperglycemic clamp variations and their applications
• Methods of testing pancreatic reserve
• Infusion of native proteins

Expert Panelists:

Dariush Elahi, M.D.
Johns Hopkins Medical School Department of Surgery & Harvard Medical School Department of Medicine

Michael R. Rickels, M.D.
Assistant Professor of Medicine
Division of Endocrinology, Diabetes & Metabolism. University of Pennsylvania School of Medicine
 
Cyril Clarke, BSc, MBBS, MFPM.
Vice President Translational Medicine, ICON Development Solutions

Clayton Dehn
Manager of Glucose Clamp Services
ICON Development Solutions

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