Design & Simulation Software

Aptiv Solutions offers fully validated software and technology solutions for the design, simulation of adaptive clinical trials.

ADDPLAN® DF – For Early Phase Dose Finding Studies

ADDPLAN DF is based on MCPmod methodology and covers model-based dose-finding designs for proof-of-concept testing and estimation of target doses in phase II clinical trials. MCPmod methodology is a preferred tool for dose-finding studies although until now fully validated design and analysis software has not been available. ADDPLAN DF will allow researchers to establish a dose response signal based on a set of candidate models while strongly controlling the type I error, an important step in maintaining trial validity.