Adaptive Design: The Faster Path to Market


Are competitors beating you to market?

An adaptive design clinical trial can help to create a stronger value proposition for your medical device and give you a competitive edge, by reducing development costs and accelerating time-to-market.

Adaptive design allows for pre-set interim analyses to assess efficacy, treatment effect and other critical data, allowing you to make better, more informed development decisions.

ICON experts have more than a decade of experience in the design, simulation and execution of adaptive design trials. Our operational teams and specialised technologies enable medical device manufacturers to apply the power of adaptive design to:

  • design seamless, multistage trials that conserve patients and remove whitespace
  • prevent underpowered and overpowered studies
  • guard against unexpectedly high sham response
  • enable effective reallocation of resources through early termination for futility or efficacy

Read the white paper and browse the case studies for greater insights and detailed examples of the value of adaptive design for medical device development.

Related Information:

Case Study: Mitigating Development Risks through Adaptive Design

When a manufacturer needed to design a trial that would accelerate the registration of its electrostimulation device, it turned to ICON’s Medical Device & Diagnostics Research group for guidance. With the help of ICON’s expert team and proprietary adaptive design software, ADDPLAN®, the client was able to save five months of development time and $1.9 million.

Case study thumbnailCase Study: Mitigating Development Risks through Adaptive Design Read the case study

Case Study: Accelerating Time to Market and Eliminating $5 Million in Development Costs through Adaptive Design

Promising initial data in a non-inferiority test for a manufacturer’s disc replacement device encouraged plans to conduct a second trial to prove superiority–a rare claim in the orthopaedics industry. ICON developed an adaptive approach that eliminated the need to conduct a separate study, ultimately reducing clinical development expenses by more than $5 million.

Case study thumbnailCase Study: Accelerating Time to Market and Eliminating $5 Million in Development Costs through Adaptive Design Read the case study