Adaptive design is a novel clinical trial approach that is supposed to maximise efficiency and portfolio value

Case Study: Avoiding Operational Errors in Adaptive Trials

Despite early signs of efficacy, an adaptive Phase III superiority trial for a new chronic graft-versus-host disease treatment failed after being halted. Learn how the erroneous early stopping decision could have been prevented.

Case Study: Avoiding Operational Errors in Adaptive Trials II

A randomised, double-blind Phase III non-inferiority trial of a new treatment for acute infectious diarrhoea against a comparator employed an adaptive design calling for two interim analyses to adjust sample size.

Case Study: Mitigating Development Risks through Adaptive Design

After running for seven years, an adaptive Phase II trial for acute infectious diarrhea fell prey to operational bias during interim analysis. Learn which procedures could have enabled the study to maintain blinding.