A Novel Approach to ALS Trial Development

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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting some 40,000 individuals in Europe at any time, causing 10,000 deaths each year. As with other age-related neurodegenerative diseases, the drug development field is littered with inconclusive or negative trials.

Modifying Immune Response and Outcomes in ALS (MIROCALS) is an international European Union H2020-funded trial of low-dose interleukin-2 in motor neurone disease (MND)/ALS. It aims to break this impasse in the development of disease-modifying agents through novel trial design, incident (early post-diagnosis) recruitment, integration of biomarkers/transcriptomics and cohort stratification. 

Join this webinar to hear about an overview of the study in addition to a discussion of the challenges – both anticipated and unanticipated – in recruiting participants recently diagnosed with a rare, rapidly disabling and ultimately life-limiting condition.

Speakers

P. Nigel Leigh, BSc, MB BS, PhD, FRCP, FAAN, FMedSci, Professor of Neurology, Brighton and Sussex Medical School

P. Nigel Leigh, BSc, MB BS, PhD, FRCP, FAAN, FMedSci -

Professor of Neurology, Brighton and Sussex Medical School

Coleader of MIROCALS, P. Nigel Leigh is Emeritus Professor at King’s College London, Honorary Consultant Neurologist at Brighton and Sussex University Hospitals Trust and Director of the Sussex MND Care and Research Network. He is also Professor of Neurology at Brighton and Sussex Medical School, since his appointment in 2011. His research continues to focus on the causes, mechanisms, and treatment of MND and related neurodegenerative disorders.

Brian Dickie, PhD, Director of Research Development, Motor Neurone Disease Association

Brian Dickie, PhD

Director of Research Development, Motor Neurone Disease Association

Brian Dickie has an academic research background in pharmacology and neuroscience. As Director of Research for the MND Association of England, Wales and Northern Ireland, he oversees a portfolio of over 90 research projects, spanning basic, clinical and healthcare research. Additional roles include raising the Association’s profile within the biomedical research community, facilitating collaborative research and communicating advances in MND research to lay and specialist audiences.