The objective of this course is to introduce advanced concepts of population pharmacokinetics in NONMEM.


Robert Bauer, PhD; Brian Sadler, PhD; Indrajit, Das, PhD

Course Objectives

The course is targeted to individuals interested in solving population PK/PD problems using the new stochastic methods.  The course is for those who are familiar with classic NONMEM methods (first order (FO)/first order conditional estimation (FOCE)/Laplace), and are familiar with constructing control stream files.

Most of the course is instructional, with several hands-on examples for attendee participation    A thorough discussion of stochastic approximation expectation maximization (SAEM), Importance sampling (IMP), and Markov chain Monte Carlo Bayesian analysis (BAYES) will be presented, along with hands-on exercises. 

After attending this course, the participant will know how to use advanced stochastic methods for analyzing population PK/PD data; structure the models into a MU-referencing format that will greatly increase the efficiency of the analyses; apply prior information from previous analyses to the present data; create population mixture models; create models for categorical data; use new abbreviated code features for easier modeling of inter-occasion variability; model additional mixed effects levels for grouping individuals, such as inter-clinical site variability; use the new DO loop feature in abbreviated code, such as for handling multiple bolus doses in transit compartment models that use the analytical absorption function. 

Additional topics covered are: parallel computing and dynamic memory allocation for efficient memory usage; symbolic referencing to thetas, etas, and sigmas; Monte Carlo search algorithms to improve FOCE estimation; built-in individual weighted residuals; bootstrap tools for simulation; and greater control in average eta shrinkage calculations.  

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  • Industry - $800
  • Academia/Government - $700
  • Student - $600 

A 15% discount is available to groups of 3 or more from the same organization

More Information / Registration

Please contact Lisa Wilhelm-Lear to register or request more information.

This course, the Beginners/Intermediate course, and the TMDD Lecture are part of one series. Interested parties may register for the first two days, the third day, the fourth day or all four days.

Deadline for Registration

September 7, 2018