This workshop will cover the description and use of features in NONMEM 7. Workshop attendees will be instructed how to specify gradient precision and how to use the FAST algorithm (new in NM 7.4) for FOCE, and will also be instructed on how to use the Monte Carlo importance sampling, stochastic approximation expectation-maximization methods, and full Bayesian methods such as Gibbs sampling and Hamiltonian no-U turn sampling (new in NM 7.4). Parallel computing and dynamic memory allocation for efficient memory usage will also be described as well as symbolic references to thetas, etas, and sigmas, priors to sigmas, MonteCarlo search algorithms to improve FOCE estimation, built-in individual weighted residuals, bootstrap tools for simulation, and automatic stabilization against numerical exceptions (new in NM 7.4).
Also, learn to use new abbreviated code features for easier modeling of inter-occasion variability, modeling additional mixed effects levels for grouping individuals, such as inter-clinical site variability, and using the DO loop feature in abbreviated code, useful for handling multiple bolus doses in models that use the analytical absorption function for multiple transit compartments. The features of PDx-POP 5.2, the graphical interface for NONMEM 7, will also be demonstrated.Download Agenda
Robert J. Bauer, PhD.
Vice President, Pharmacometrics, Research and Development (R&D), ICON plc
Robert Bauer (Robert.Bauer@iconplc.com) holds a PhD. in Pharmacology. He heads the Pharmacometrics R&D department at ICON Plc, Gaithersburg, MD, where he and his group maintain the population analysis software NONMEM®, incorporating leading edge algorithms in pharmacometrics. Dr. Bauer’s focus is on developing and implementing mathematical and statistical algorithms for biomedical problems.
Brian M. Sadler, PhD.
Sr. Scientific Director, Pharmacokinetics, Pharmacodynamics, Modeling & Simulation, ICON plc
Brian Sadler, Ph.D., Senior Scientific Director, Pharmacokinetics, Pharmacodynamics, Modeling and Simulation, joined ICON in 2010 and brings 37 years of relevant experience from the perspectives of his previous positions as a PKDM scientist at RTI International, a project pharmacokineticist at GlaxoSmithKline, an instructor and domain expert at a Pharsight, and as the principal and owner of his own pharmacometric consulting company. Dr. Sadler earned his Ph.D. in Pharmacology and B.A. in Biology from the University of Missouri - Columbia.
The fees associated with this workshop are as follows:
- US$500 (industry price)
- US$250 (academia price)
- US$100 (student price)
Each participant will need to bring a laptop and charger, preferably Windows based.