The Institute for Clinical and Economic Review (ICER) is a major force in payer–manufacturer price negotiations. In a 2018 ICON plc survey of more than 20 U.S. payers, more than three quarters of respondents said that they would use an ICER cost-effectiveness threshold as a basis for negotiating a rebate contract. Read more from ICON's Nathan White, Adam Johns, and Eric Latch in the September 2018 issue of Managed Care.