Clinical & scientific operations case studies

Maximising patient recruitment and retention, and expanding access to diverse patient populations.

We work with you to develop strategic, flexible approaches that leverage clinical informatics, state-of-the-art technologies, and our global reach to make data-driven decisions for every study.

Re-adjudicating a respiratory and cardiovascular trial during COVID-19

The FDA advised the trial to re-adjudicate so that the study accounted for the effects of COVID-19 on the trial outcomes. To ensure that the trial data would be submitted to the FDA as scheduled, ICON needed to coordinate re-adjudication of 700 endpoints within a compressed three-month timeline.

Automating EDC user access for improved trial efficiency

This case study demonstrates how ICON automated EDC user access management using API integrations and workflow automation, enhancing efficiency, security, compliance, and scalability in clinical trials while reducing costs and delays.

Overcoming activation and enrollment delays

ICON partnered with a drug development sponsor to conduct a global programme for Multiple sclerosis (MS) studies in over 2,200 patients.

Securing the CRA talent pipeline in the US for a pharmaceutical company

A multinational pharmaceutical company, of ICON’s functional services provider clients, approached our team to resource CRAs in the US.

Safety reporting continuity to protect patient safety and maintain compliance

Scientists are working diligently to learn more about the Coronavirus and health boards are changing guidance to adapt to
this newly available information.

Accelerating site proposal and selection

Timely patient recruitment is crucial to maintaining clinical trial timelines and budgets, but selecting the best and most engaged sites is challenging. Learn how ICON's proprietary One Search platform addresses this by aggregating and cleaning data from multiple sources.

The ICON safety reporting solution

ICON's Safety Reporting Solution ensured regulatory compliance during global trials by adapting to pandemic-related disruptions.

Flexible, robust and rapid IRT solution for an international infectious disease trial

ICON was tasked with providing a rapid and flexible IRT solution for a multinational infectious disease vaccine trial with over 30,000 subjects in 100+ locations.

Prioritising efficiency and flexibility in safety data signal detection

ICON collaborated with a small US-based pharmaceutical company to conduct safety signal detection and management during the clinical development of four neurodegenerative disease compounds, using SIGNET.

Effective collaboration on Clinical Data Standards governance

ICON's Global Data Standards team helped a large pharmaceutical company consolidate multiple standards libraries into a single, harmonized library used across therapeutic areas.

ICON implements new Lay Protocol Synopsis (LPS) program

Increased trial transparency has been a growing industry trend for many years. The largest recent initiative in this realm
is the European Medicines Agency’s (EMA’s) Clinical Trials Information System (CTIS), which went online in January
2022.