Formulations in early clinical development require a delicate balance of flexibility, simplicity, and scientific rigor. In first‑in‑human trials, dose ranges can vary by 10–100 fold increase between the starting dose a...
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Shifting paradigms of clinical trial design accelerate CNS R&D
Meeting the demand for clinically relevant neurodegenerative treatments requires a paradigm shift in how central nervous system (CNS) clinical trials have been designed and executed. Bill Holt outlines how drug developers are now at the forefront of adopting more nuanced, cost-effective, and patient-centric clinical trial designs.
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Comment: Realising the full potential of biomarker-informed clinical trials for neurodegenerative disorders
This article by Peter Schueler is based on the recent whitepaper, “Early, precise and efficient; the methods and technologies advancing Alzheimer’s and Parkinson’s R&D”. It explores how the recent approval of amyloid-targeting monoclonal antibodies for Alzheimer’s, following decades of failed trials, can be partially attributed to the development of improved biomarkers for patient screening and outcomes assessment.
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The role of digital therapeutics in central nervous system clinical trials
In this article, ICON's Louisa Steinberg and Maureen Glynn consider the role of digital therapeutics in the treatment of central nervous system conditions and how they can be used to improve clinical trials.
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Why pursuit of meaningful Alzheimer’s therapies is gathering pace
In this article in Neuro Rehab Times, ICON expert, Peter Schüler, reflects on the potential implications of new Alzheimer’s therapies on the research landscape.
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The role of digital health technology tools in supporting medical adherence
In this article in Pharmaceutical Market Europe, Dr Peter Schueler and Dr Isaac R Rodriguez Chavez outline the role of digital health technology tools in supporting medical adherence. 2022 PM Group
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The growing potential of neurological biomarkers as surrogate endpoints for accelerated drug development
This article by Dr. Peter Schueler explores how digital and liquid biomarkers are developing, and how they can impact the future of neurological studies.
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Alzheimer’s: the search for a cure
An interview in which Peter Schueler discusses the current landscape of Alzheimer’s research and recently published study results.
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Engaging the crowds
A thought leadership piece by Peter Schueler which considers the importance of patient engagement and enrollment in Alzheimer's clinical trials.
This article is taken from International Clinical Trials November 2020, pages 10-12. © Samedan Ltd.
