All case studies

Highlights

We focus our innovation on the factors that matter most — accelerating time to market, reducing costs and enhancing quality. Learn more about how we've helped clients meet and exceed their goals in this selected library of case studies.

Proactive patient retention strategy in a GLP-1 RA trial

Explore how ICON successfully supported a sponsor’s cardiovascular outcome trial for a GLP-1 receptor agonist with 9,900+ patients with type 2 diabetes and maintained a retention rate of 97% over 7 years.

A small biotech success story

A small US-based biotech company was in a race to be the first to market with their lead targeted oncology product.

FSP partnership - sustained efficiency and ongoing innovation

The implementation of an FSP model across our partner's project management function, led to 20% cost efficiences and a 30% reduction in client burden.

By taking a site and patient-centric approach, and leveraging advanced tools and real-time data insights, we maximise patient access, recruitment, and retention—ensuring that every trial is conducted with efficiency, agility, and a commitment to improving patient outcomes.

All case studies

Filter our case studies by categories, selecting amongst our broad range of solutions.

Re-adjudicating a respiratory and cardiovascular trial during COVID-19

The FDA advised the trial to re-adjudicate so that the study accounted for the effects of COVID-19 on the trial outcomes. To ensure that the trial data would be submitted to the FDA as scheduled, ICON needed to coordinate re-adjudication of 700 endpoints within a compressed three-month timeline.

Automating EDC user access for improved trial efficiency

This case study demonstrates how ICON automated EDC user access management using API integrations and workflow automation, enhancing efficiency, security, compliance, and scalability in clinical trials while reducing costs and delays.

Safety reporting continuity to protect patient safety and maintain compliance

Scientists are working diligently to learn more about the Coronavirus and health boards are changing guidance to adapt to
this newly available information.

Accelerating site proposal and selection

Timely patient recruitment is crucial to maintaining clinical trial timelines and budgets, but selecting the best and most engaged sites is challenging. Learn how ICON's proprietary One Search platform addresses this by aggregating and cleaning data from multiple sources.

The ICON safety reporting solution

ICON's Safety Reporting Solution ensured regulatory compliance during global trials by adapting to pandemic-related disruptions.

Flexible, robust and rapid IRT solution for an international infectious disease trial

ICON was tasked with providing a rapid and flexible IRT solution for a multinational infectious disease vaccine trial with over 30,000 subjects in 100+ locations.

Prioritising efficiency and flexibility in safety data signal detection

ICON collaborated with a small US-based pharmaceutical company to conduct safety signal detection and management during the clinical development of four neurodegenerative disease compounds, using SIGNET.

Effective collaboration on Clinical Data Standards governance

ICON's Global Data Standards team helped a large pharmaceutical company consolidate multiple standards libraries into a single, harmonized library used across therapeutic areas.

IRT User Acceptance Testing

Resolving critical issues and ensuring trial integrity

Evolving quality oversight to limit sponsor burden

ICON implemented a Data Management Asset Lead (DMAL) role to provide oversight and ensure adherence to standards for a sponsor with limited bandwidth.

Applying statistical and programming expertise to overcome FDA challenges

ICON supported a biotech company in preparing for FDA submission by quickly mobilising a team to address unexpected comments on statistical analysis and data collection, resulting in timely BLA submission, enhanced data quality, and alignment with FDA requirements.

The importance of CRF design in cell and gene therapy studies

ICON partnered with a biotech sponsor to optimise Case Report Forms (CRFs) for an oncology cell and gene therapy trial. By adopting iRECIST criteria and standardising CRF templates, we reduced data duplication, ensured accuracy, and provided flexibility for subject re-treatment.

Solutions case studies

Our solutions span the entire lifecycle of product development and can be adapted to suit small local trials or large global programs. Explore our work in the different aspects of our solutions.

Let's collaborate

Discover how ICON's expertise transforms clinical trials.

Blogs

Stay informed with ICON's expert insights on clinical trials, regulatory changes, and industry trends. Our blogs provide practical advice, innovative solutions, and thought leadership from global experts.

News

Stay updated with our latest news on partnerships, financial results, technological advancements, and industry insights.

Insights

Explore ICON's expert analysis and practical advice on the latest operational, regulatory, technological and economic challenges in clinical research. Our insights provide thought leadership and innovative solutions to transform trials.

Case studies

Highlights

Proactive patient retention strategy in a GLP-1 RA trial

A small biotech success story

FSP partnership - sustained efficiency and ongoing innovation

All case studies

Re-adjudicating a respiratory and cardiovascular trial during COVID-19

Automating EDC user access for improved trial efficiency

Safety reporting continuity to protect patient safety and maintain compliance

Accelerating site proposal and selection

The ICON safety reporting solution

Flexible, robust and rapid IRT solution for an international infectious disease trial

Prioritising efficiency and flexibility in safety data signal detection

Effective collaboration on Clinical Data Standards governance

IRT User Acceptance Testing

Evolving quality oversight to limit sponsor burden

Applying statistical and programming expertise to overcome FDA challenges

The importance of CRF design in cell and gene therapy studies

Solutions case studies

Let's collaborate

Blogs

News

Insights