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Metabolites

Metabolite profiling & identification for confident drug development

ICON delivers comprehensive metabolite profiling and identification services that help you generate regulatory-ready data following your human ADME trial. 

By combining advanced LCMS, HRMS, and total radioactivity analysis, we provide fast, accurate insights into drug metabolism—empowering smarter decisions and smoother approvals.

Actionable metabolic insights

Using liquid scintillation counting (LSC) in combination with HPLC/UPLC, we analyse urine, feces, and plasma samples to determine the relative abundance of parent compounds and metabolites across biological matrices. This enables:

  • Clear understanding of metabolic pathways
  • Robust data for regulatory submissions
  • Confident assessment of drug safety and efficacy
  • High-resolution characterisation

Our use of high-resolution mass spectrometry (HRMS) allows for precise metabolite identification, supporting detailed characterisation and compliance with regulatory expectations.

Micro-tracer study support

For micro-tracer designs, ICON partners with qualified vendors to offer accelerated mass spectrometry (AMS) services. We manage the full workflow—from vendor coordination and sample processing to logistics and reporting—delivering sensitive detection of low-level metabolites, reliable profiling and identification and streamlined operations and faster timelines.

Get fast, accurate insights with ICON’s advanced metabolite profiling services.

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