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PDx-Pop

Companion graphical interface for NONMEM® to execute, evaluate and visualise population PK/PD modelling and analysis

PDx-Pop is the companion graphical interface for NONMEM®

PPDx-Pop software seamlessly integrates with existing tools and its own automated methods to expedite the iterative process of population pharmacokinetic modelling and analysis.
Working in concert with NONMEM®, the “gold standard” in Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic modelling, R and/or S-Plus® for graphics and statistics and MS Word® and Excel®, PDx-Pop, available in Windows, Linux & Mac OS, delivers optimal flexibility with increased efficiency and functionality.
 

PDx-Pop 5.4 is fully compatible and synergistic with NONMEM 7.4 and higher.
 

Main Features in PDx-Pop 5.4

  • Project management tools, including connection to Version control software Git
  • Visibility of complete project path for easy project identification, especially in a multi-user environment
  • User input will be retained for a future session, to readily resume activities
  • Comparing two or more runs’ results numerically side-by-side
  • Plotting NONMEM results with GUI wizard
  • Diagnostic plots rendered in R basic plot or ggplot format
  • Evaluation tools such as visual predictive checks, bootstrap, Wald analysis, objective function profiling, multiple MCMC chains analysis
  • In-built control stream editor with syntax color coding
  • Summary output of model, and population parameters and their standard errors produced in table form
     

Data management interface

  • Add, remove and copy projects, files & directories with user-friendly GUI
  • Quickly view, edit or plot datasets in R, S-Plus and MS Excel for initial exploration of data
  • Easily perform a single split of a dataset to create an index and validation dataset for modelling and model validation steps or multiple splits for model evaluation methods
     

Modeling interface

  • View, edit, copy control streams using syntax color-coded editor
  • Automate the creation and error proofing of control streams with control stream wizards or use a standard template
  • Easy implementation of NONMEM 7 additional command line arguments via checkboxes and text field
  • Run batches in parallel on multi-core systems to save time
  • Point-and-click to easily select, prioritize and compile the control streams to be run: individually or in batches
  • View progress before analysis is complete through View Intermediate Results feature or real-time plotting of the objective function value or any model parameter as a function of the iteration number
  • Stop NONMEM runs gently or abort them, turning on-or-off iterations to show on the console using buttons

Output interface

  • Output produced in formats designed to streamline the analysis and reporting process
  • Standard NONMEM results with additional information on the control stream used
  • Enhanced Output Summary Results: including final estimates for theta, omega and sigma and their associated standard deviation, %CV, %RSE, intervals, AIC and SBC
  • Fully automated diagnostic plots using R
  • Automated R and S-Plus plots of estimated parameters (qqplots, histograms) and etas (pairs plots, histograms)
  • Automated R and S-Plus plot comparisons between two runs
  • Automated Bayesian parameter history plots
  • Access Custom User-written R and S-Plus scripts from PDx-Pop
     

Model evaluation interface

  • Parallelized and automated bootstrap analysis to determine intervals of parameters, using NONMEM’s $SIM implementation with full range of arguments or classical PDx-Pop randomization of subjects
  • Automated objective function profiling and to determine asymmetric confidence intervals
  • Parallelized and automated leverage analysis to determine model stability and influence of atypical individuals
  • Parallelized and automated random initial parameter estimate variation
  • Automated Visual Predictive Check implementation with regular, prediction-corrected and standardized methods
  • Parallelized and automated WALD approximation methodology implemented to aid in covariate model building
  • Parallelized and automated Multiple MCMC Chains analysis
  • Stop NONMEM runs gently or abort them, turning on-or-off iterations to show on the console using buttons
  • Easy implementation of NONMEM 7.6 additional command line arguments via checkboxes and text field
     

Tracking & audit trail

  • The Run Log tracks all steps in the analysis. View, print or save this important information as a file.
  • Maintain an electronic journal associated with the analysis to record important information: comments on runs, models used, decisions made on outputs, etc.
     

Tools and utilities

  • Graphical NONMEM installation wizard for multiple versions and Fortran compiler tester for all compilers
  •  PDF format PDx-Pop User Manual, support document, and “tool tips” accessible through the interface
  • HTML and PDF version of NONMEM help accessible through the interface
  • System diagnostics test to trouble-shoot potential configuration issues
  • Library of NONMEM control streams and data for all standard NONMEM models
     

System requirements

Platform

  • Intel or AMD Pentium processor with minimum 1 GB of RAM (2 GB for Windows Vista or 7)
  • Windows XP, Vista 7-11, Linux, or macOS
  • Graphics card and monitor capable of minimum resolution of 1280x800.
  • CD-ROM disk drive
  • Microsoft Mouse or other compatible pointing device
  • ~300 MB, on Windows & Linux/UNIX, or ~500 MB, on macOS, free disk space required (Interface space = 25 MB)
  • ~100 MB of swap space/virtual memory
     

Required software

  • NONMEM 7.4 or higher
  • Intel Visual Fortran* (versions 8.0 or higher), gfortran (version 4.5.0 or higher)

  • Internet Explorer 7.0 or higher or any other browser

     

Recommended software

  • R version 4.0.0 (or higher)
  • Xpose 4.0 for R

* Intel Visual Fortran requires Microsoft Visual Studio

PDx by ICON plc. is a registered trademark. NONMEM is a registered trademark of the Regents of the University  of California. Windows, Windows Vista, Windows 2000, Windows XP, Microsoft Word, and Microsoft Excel are either registered  trademarks or trademarks of Microsoft Corporation. S-PLUS is a registered trademark of Insightful Corporation.

Contact

+1 301 944 6810 or email us at idssoftware@iconplc.com

 

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