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Metabolic disease

Advanced imaging expertise for metabolic diseases

ICON is a trusted leader in clinical imaging for metabolic disease research, with decades of experience supporting pharmaceutical and biotech partners in the development of innovative therapies.

  • 92

    studies

  • 5,000

    sites

  • 40,000

    subjects

Pioneering imaging innovation in metabolic research

ICON led the first multi-site MRI-PDFF study in 2010 and has supported numerous musculoskeletal trials quantifying both muscle and fat. Our capabilities extend to ECHO, cardiovascular MRI (CVMR), and long-term continuous arrhythmia monitoring, ensuring comprehensive metabolic and cardiovascular profiling.

Precision imaging for obese patients

Imaging obese patients in metabolic studies presents unique challenges. High BMI can affect image quality, limit scanner access, and complicate positioning. Standard equipment may not accommodate larger body sizes, risking incomplete data. ICON addresses these issues with specialized protocols and infrastructure—delivering reliable, high-quality imaging while prioritising patient comfort and inclusion.

  • Customised imaging protocols for high BMI populations
  • State-of-the-art equipment calibrated for body composition and organ-specific imaging
  • Expert radiology teams trained in metabolic disease markers
  • Seamless integration with clinical trial workflows and data systems
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Supporting drug development with reliable imaging data

From early-phase trials to late-stage studies, ICON provides imaging services that help sponsors assess drug efficacy, monitor disease progression, and evaluate treatment response. Our work includes:

  • MRI and CT scans for liver fat quantification and visceral adiposity
  • Ultrasound imaging for cardiovascular and hepatic assessments
  • DEXA scans for body composition analysis
  • PET imaging for metabolic activity and inflammation tracking

Our end-to-end imaging solutions streamline acquisition, ensure consistency across sites, and leverage AI-driven analysis to accelerate insights. We help sponsors minimise trial delays, enhance decision-making, and meet stringent regulatory requirements with robust, data-backed evidence.

Obesity and weight loss imaging

With deep experience across dozens of clinical trials, our teams specialize in imaging obese populations and understanding the complexities of body composition. This expertise is critical for accurately evaluating the impact of weight loss therapies and advancing obesity research.

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Driving MASH trials with imaging expertise

As a recognised expert in imaging-based quantification of hepatic biomarkers for MASH, we bring deep scientific knowledge and global operational strength to support your trial. Our experience in MASH imaging ensures access to validated biomarkers and proven best practices—accelerating development and helping bring treatments to patients faster.

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Obesity and metabolic-dysfunction associated steatotic liver disease.
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