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MASH/MASLD

Multi-modal image acquisition and processing expertise in MASH and obesity assessments

MASH/MASLD Imaging experience in the last five years:

  • 32

    Clinical trials

  • 24,628

    Patients

  • 1,582

    Sites

ICON is the global leader in hepatology and MASH clinical development. As a leader in imaging-based quantification of hepatic biomarkers of MASH, we strengthen your trial with unparalleled experience and global operational support. Our scientific expertise and experience in MASH imaging trials provides the relevant biomarkers and best practices needed to drive your programme forward, and ultimately make treatment options available to patients faster.

We have medical imaging expertise with specializations in multi-modal image acquisition (MRI-PDFF, MRE, MRS, CT, Ultrasound and DXA) and processing expertise in MASH and obesity assessments. Our study teams provide quantitative imaging analyses for liver disorders such as metabolic (dysfunction)-associated fatty liver disease (MAFLD) and MASH, with liver endpoint measurements including hepatic fat and stiffness assessments as well as liver and spleen volumes.

We collaborate with experienced radiologists to provide comprehensive imaging solutions that can provide non- invasive evidence of drug efficacy. Incorporating such non-invasive imaging biomarkers at an earlier phase of study provides more timely insights into the efficacy of the drug under consideration.

Delivering benefits to your MASH trial:

 

Multimodal imaging expertise
Support for MASH trials across MRI-PDFF, MRE, MRS, CT, ultrasound, and DXA, enabling comprehensive assessment of liver, metabolic, and body composition endpoints.

Robust site certification and standardisation
Structured site certification using Calimetrix PDFF and standardised MRE phantoms to support consistency in image acquisition across study sites.

Documented training and quality control
Comprehensive site training, documentation, and robust QC processes help support reliable image acquisition, submission, and data quality throughout the trial.

End-to-end phantom and image data support
Integrated collection, QC, and processing of both phantom data and study images to support consistent imaging workflows and endpoint delivery.

Specialist quantitative image processing
Expert in-house quantitative processing capabilities, with external vendor support leveraged when required, to support complex MASH imaging assessments.

Comprehensive liver and body composition assessments
Quantitative assessment of segmental liver fat, liver stiffness, visceral fat, subcutaneous fat, intra- and inter-muscular fat, muscle, liver, and spleen volumes.

Central reader and expert oversight
Access to a panel of central readers and key opinion leaders with relevant expertise in liver, metabolic, and imaging-based clinical trials.

Experienced MASH trial support
Leverage ICON’s knowledge and operational experience across MASH trials to support study planning, imaging implementation, quality oversight, and delivery.

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